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Research Article

L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression

  • Fang Du,

    Affiliation: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong

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  • Zhong-ming Qian mail,

    bczmqian@polyu.edu.hk (Z-mQ); yake@cuhk.edu.hk (KY)

    Affiliations: Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong, Department of Neurobiology and Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, People's Republic of China

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  • Li Zhu,

    Affiliations: Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong, Department of Neurobiology and Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, People's Republic of China

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  • Xiao Mei Wu,

    Affiliation: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong

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  • Wing-ho Yung,

    Affiliation: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong

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  • Ting-yuk Tsim,

    Affiliation: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong

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  • Ya Ke mail

    bczmqian@polyu.edu.hk (Z-mQ); yake@cuhk.edu.hk (KY)

    Affiliation: Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong

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  • Published: February 25, 2009
  • DOI: 10.1371/journal.pone.0004593

About the Authors

Fang Du, Xiao Mei Wu, Wing-ho Yung, Ting-yuk Tsim, Ya Ke
Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong
Zhong-ming Qian, Li Zhu
Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Kowloon, Hong Kong
Zhong-ming Qian, Li Zhu
Department of Neurobiology and Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, People's Republic of China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZMQ YK. Performed the experiments: FD LZ XMW WhY TyT. Analyzed the data: ZMQ YK. Contributed reagents/materials/analysis tools: WhY. Wrote the paper: ZMQ YK.