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Research Article

APOMAB®, a La-Specific Monoclonal Antibody, Detects the Apoptotic Tumor Response to Life-Prolonging and DNA-Damaging Chemotherapy

  • Fares Al-Ejeh,

    Affiliation: Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, South Australia, Australia

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  • Jocelyn M. Darby,

    Affiliation: Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, South Australia, Australia

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  • Chris Tsopelas,

    Affiliation: Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

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  • Douglas Smyth,

    Affiliation: Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

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  • Jim Manavis,

    Affiliation: Centre for Neurological Disease, Hanson Institute, Adelaide, South Australia, Australia

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  • Michael P. Brown mail

    michael.brown@health.sa.gov.au

    Affiliations: Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, South Australia, Australia, Department of Medical Oncology, Royal Adelaide Hospital Cancer Centre and School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

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  • Published: February 27, 2009
  • DOI: 10.1371/journal.pone.0004558

About the Authors

Fares Al-Ejeh, Jocelyn M. Darby, Michael P. Brown
Experimental Therapeutics Laboratory, Hanson Institute, Adelaide, South Australia, Australia
Chris Tsopelas, Douglas Smyth
Department of Nuclear Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Jim Manavis
Centre for Neurological Disease, Hanson Institute, Adelaide, South Australia, Australia
Michael P. Brown
Department of Medical Oncology, Royal Adelaide Hospital Cancer Centre and School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

Corresponding Author

Email: michael.brown@health.sa.gov.au

Competing Interests

FA, JMD, and MPB are named as inventors on patent applications, which are licensed to Oncaidia. FA and MPB are members of the scientific advisory board of Oncaidia.

Author Contributions

Conceived and designed the experiments: FAE MPB. Performed the experiments: FAE JMD CT DS JM. Analyzed the data: FAE JMD CT DS JM MPB. Contributed reagents/materials/analysis tools: FAE CT DS JM. Wrote the paper: FAE CT MPB.