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Research Article

Possible Novel Therapy for Malignant Gliomas with Secretable Trimeric TRAIL

  • Moonsup Jeong,

    Affiliations: Biopharmaceutical Research Laboratories of Dong-A Pharmaceutical Co., Ltd., Kyunggi-Do, Korea, Department of Neurosurgery, The Catholic University of Korea, Seoul, Korea

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  • Yong-Sam Kwon,

    Affiliation: Biopharmaceutical Research Laboratories of Dong-A Pharmaceutical Co., Ltd., Kyunggi-Do, Korea

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  • Soon-Hye Park,

    Affiliation: Biopharmaceutical Research Laboratories of Dong-A Pharmaceutical Co., Ltd., Kyunggi-Do, Korea

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  • Chae-Young Kim,

    Affiliation: Biopharmaceutical Research Laboratories of Dong-A Pharmaceutical Co., Ltd., Kyunggi-Do, Korea

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  • Sin-Soo Jeun,

    Affiliation: Department of Neurosurgery, The Catholic University of Korea, Seoul, Korea

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  • Kang-Won Song,

    Affiliation: Department of Neurosurgery, Hanyang University Medical Center, Seoul, Korea

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  • Yong Ko,

    Affiliation: Department of Neurosurgery, Hanyang University Medical Center, Seoul, Korea

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  • Paul D. Robbins,

    Affiliation: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Timothy R. Billiar,

    Affiliation: Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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  • Byong-Moon Kim mail,

    bmkim@donga.co.kr (BMK); seold@kyungwon.ac.kr or (DWS)

    Affiliation: Biopharmaceutical Research Laboratories of Dong-A Pharmaceutical Co., Ltd., Kyunggi-Do, Korea

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  • Dai-Wu Seol mail

    bmkim@donga.co.kr (BMK); seold@kyungwon.ac.kr or (DWS)

    Affiliations: Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Life Science, Kyungwon University, Kyunggi-Do, Korea, Gachon BioNano Research Institute, Kyungwon University, Kyunggi-Do, Korea

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  • Published: February 20, 2009
  • DOI: 10.1371/journal.pone.0004545

About the Authors

Moonsup Jeong, Yong-Sam Kwon, Soon-Hye Park, Chae-Young Kim, Byong-Moon Kim
Biopharmaceutical Research Laboratories of Dong-A Pharmaceutical Co., Ltd., Kyunggi-Do, Korea
Moonsup Jeong, Sin-Soo Jeun
Department of Neurosurgery, The Catholic University of Korea, Seoul, Korea
Kang-Won Song, Yong Ko
Department of Neurosurgery, Hanyang University Medical Center, Seoul, Korea
Paul D. Robbins
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Timothy R. Billiar, Dai-Wu Seol
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
Dai-Wu Seol
Department of Life Science, Kyungwon University, Kyunggi-Do, Korea
Dai-Wu Seol
Gachon BioNano Research Institute, Kyungwon University, Kyunggi-Do, Korea

Corresponding Authors

Competing Interests

Authors Moonsup Jeong, Yong-Sam Kwon, Soon-Hye Park, Chae-Young Kim & Byong-Moon Kim are employees of Dong-A Pharmaceutical Co. Ltd. Dai-Wu Seol is a patent holder of stTRAIL. The other authors declare no competing financial interests.

Author Contributions

Conceived and designed the experiments: SSJ PDR TB BMK DWS. Performed the experiments: MJ YSK SHP CYK KWS YK DWS. Analyzed the data: MJ YSK SHP CYK SSJ KWS YK PDR TB BMK DWS. Contributed reagents/materials/analysis tools: PDR DWS. Wrote the paper: SSJ PDR TB BMK DWS.