Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

William Mair; Siler H. Panowski; Reuben J. Shaw; Andrew Dillin

doi:10.1371/journal.pone.0004535

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Peer-reviewed

Research Article

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

William Mair ,

* E-mail: mair@salk.edu (WM); dillin@salk.edu (AD)

Affiliations Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, The Howard Hughes Medical Institute, La Jolla, California, United States of America
⨯
Siler H. Panowski,

Affiliations Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, The Howard Hughes Medical Institute, La Jolla, California, United States of America
⨯
Reuben J. Shaw,

Affiliation Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
⨯
Andrew Dillin

* E-mail: mair@salk.edu (WM); dillin@salk.edu (AD)

Affiliations Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, The Howard Hughes Medical Institute, La Jolla, California, United States of America
⨯

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegans

William Mair,
Siler H. Panowski,
Reuben J. Shaw,
Andrew Dillin

Published: February 20, 2009
https://doi.org/10.1371/journal.pone.0004535

About the Authors

William Mair

* E-mail: mair@salk.edu (WM); dillin@salk.edu (AD)

Affiliations Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America, The Howard Hughes Medical Institute, La Jolla, California, United States of America

Siler H. Panowski

Reuben J. Shaw

Affiliation Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America

Andrew Dillin

* E-mail: mair@salk.edu (WM); dillin@salk.edu (AD)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WM SHP RS AD. Performed the experiments: WM SHP. Analyzed the data: WM SHP. Wrote the paper: WM SHP AD.

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Food
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Aging
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Caenorhabditis elegans
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Eggs
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Epistasis
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Regulator genes
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Larvae
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Diet
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