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Research Article

Prion Protein Modulates Cellular Iron Uptake: A Novel Function with Implications for Prion Disease Pathogenesis

  • Ajay Singh equal contributor,

    equal contributor Contributed equally to this work with: Ajay Singh, Maradumane L. Mohan

    Affiliation: The Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Maradumane L. Mohan equal contributor,

    equal contributor Contributed equally to this work with: Ajay Singh, Maradumane L. Mohan

    Affiliation: The Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Alfred Orina Isaac,

    Affiliation: The Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Xiu Luo,

    Affiliation: The Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Jiri Petrak,

    Affiliation: Department of Pathological Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    X
  • Daniel Vyoral,

    Affiliation: Department of Pathological Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    X
  • Neena Singh mail

    neena.singh@case.edu.

    Affiliation: The Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

    X
  • Published: February 12, 2009
  • DOI: 10.1371/journal.pone.0004468

About the Authors

Ajay Singh, Maradumane L. Mohan, Alfred Orina Isaac, Xiu Luo, Neena Singh
The Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America
Jiri Petrak, Daniel Vyoral
Department of Pathological Physiology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

Corresponding Author

Email: neena.singh@case.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NS. Performed the experiments: AS MLM AOI XL JP NS. Analyzed the data: AS MLM AOI JP DV NS. Contributed reagents/materials/analysis tools: DV. Wrote the paper: NS.