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Research Article

Plasma Neutrophil Elastase and Elafin Imbalance Is Associated with Acute Respiratory Distress Syndrome (ARDS) Development

  • Zhaoxi Wang mail,

    mikewang@hsph.harvard.edu

    Affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Feng Chen,

    Affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Rihong Zhai,

    Affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Lingsong Zhang,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Li Su,

    Affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Xihong Lin,

    Affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Taylor Thompson,

    Affiliation: Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • David C. Christiani

    Affiliations: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America, Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: February 06, 2009
  • DOI: 10.1371/journal.pone.0004380

About the Authors

Zhaoxi Wang, Feng Chen, Rihong Zhai, Li Su, David C. Christiani
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
Lingsong Zhang, Xihong Lin
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
Taylor Thompson, David C. Christiani
Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
David C. Christiani
Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: mikewang@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZW RZ LS BTT DCC. Performed the experiments: ZW RZ LS. Analyzed the data: ZW FC RZ LZ XL. Wrote the paper: ZW BTT DCC.