About the Authors

Jonathan E. Foley

Contributed equally to this work with: Jonathan E. Foley, Jing-Ruey J. Yeh

Affiliation Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Jing-Ruey J. Yeh

Contributed equally to this work with: Jonathan E. Foley, Jing-Ruey J. Yeh

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Morgan L. Maeder

Affiliation Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Deepak Reyon

Affiliation Department of Genetics, Development and Cell Biology, Interdepartmental Graduate Program in Bioinformatics and Computational Biology, Iowa State University, Ames, Iowa, United States of America

Jeffry D. Sander

Affiliation Department of Genetics, Development and Cell Biology, Interdepartmental Graduate Program in Bioinformatics and Computational Biology, Iowa State University, Ames, Iowa, United States of America

Randall T. Peterson

Affiliations Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

J. Keith Joung

jjoung@partners.org

Affiliations Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

J.K.J. is an inventor on patent applications which describe the OPEN zinc finger engineering method. All other authors have no competing interests to declare.

Author Contributions

Conceived and designed the experiments: JEF JRJY MLM DR JDS RTP JKJ. Performed the experiments: JEF JRJY MLM DR JDS. Analyzed the data: JEF JRJY MLM DR JDS RTP JKJ. Contributed reagents/materials/analysis tools: MLM DR JDS RTP JKJ. Wrote the paper: JEF JRJY JDS RTP JKJ.