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Research Article

Facilitated Monocyte-Macrophage Uptake and Tissue Distribution of Superparmagnetic Iron-Oxide Nanoparticles

  • Arnaud Beduneau,

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Zhiya Ma,

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Cassi B. Grotepas,

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Alexander Kabanov,

    Affiliations: Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Barrett E. Rabinow,

    Affiliation: Baxter Healthcare Corporation, Round Lake, Illinois, United States of America

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  • Nan Gong,

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • R. Lee Mosley,

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Huanyu Dou,

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Michael D. Boska mail,

    mboska@unmc.edu (MDB); hegendel@unmc.edu (HEG)

    Affiliations: Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

    X
  • Howard E. Gendelman mail

    mboska@unmc.edu (MDB); hegendel@unmc.edu (HEG)

    Affiliations: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Published: February 02, 2009
  • DOI: 10.1371/journal.pone.0004343

About the Authors

Arnaud Beduneau, Zhiya Ma, Cassi B. Grotepas, Nan Gong, R. Lee Mosley, Huanyu Dou, Howard E. Gendelman
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
Alexander Kabanov
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
Michael D. Boska
Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
Arnaud Beduneau, Zhiya Ma, Cassi B. Grotepas, Nan Gong, R. Lee Mosley, Huanyu Dou, Michael D. Boska, Howard E. Gendelman
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
Alexander Kabanov, R. Lee Mosley, Huanyu Dou, Michael D. Boska, Howard E. Gendelman
Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
Barrett E. Rabinow
Baxter Healthcare Corporation, Round Lake, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB ZM AK BR MB HEG. Performed the experiments: AB ZM CG NG HD MB. Analyzed the data: AB ZM CG RLM HD MB HEG. Contributed reagents/materials/analysis tools: ZM BR. Wrote the paper: AB RLM MB HEG.