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Research Article

IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity

  • Lisa F. P. Ng equal contributor mail,

    equal contributor Contributed equally to this work with: Lisa F. P. Ng, Angela Chow

    lisa_ng@immunol.astar.edu.sg (LFPN); Yee_Sin_Leo@ttsh.com.sg (YSL)

    Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

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  • Angela Chow equal contributor,

    equal contributor Contributed equally to this work with: Lisa F. P. Ng, Angela Chow

    Affiliation: Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, Singapore

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  • Yong-Jiang Sun,

    Affiliation: Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, Singapore

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  • Dyan J. C. Kwek,

    Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

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  • Poh-Lian Lim,

    Affiliation: Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, Singapore

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  • Frederico Dimatatac,

    Affiliation: Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, Singapore

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  • Lee-Ching Ng,

    Affiliation: Environmental Health Institute, Singapore, Singapore

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  • Eng-Eong Ooi,

    Affiliation: DSO National Laboratories, Singapore, Singapore

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  • Khar-Heng Choo,

    Affiliation: Institute for Infocomm Research, A*STAR, Singapore, Singapore

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  • Zhisheng Her,

    Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

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  • Philippe Kourilsky,

    Affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

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  • Yee-Sin Leo mail

    lisa_ng@immunol.astar.edu.sg (LFPN); Yee_Sin_Leo@ttsh.com.sg (YSL)

    Affiliation: Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, Singapore

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  • Published: January 21, 2009
  • DOI: 10.1371/journal.pone.0004261

About the Authors

Lisa F. P. Ng, Dyan J. C. Kwek, Zhisheng Her, Philippe Kourilsky
Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
Angela Chow, Yong-Jiang Sun, Poh-Lian Lim, Frederico Dimatatac, Yee-Sin Leo
Tan Tock Seng Hospital, Communicable Disease Centre, Singapore, Singapore
Lee-Ching Ng
Environmental Health Institute, Singapore, Singapore
Eng-Eong Ooi
DSO National Laboratories, Singapore, Singapore
Khar-Heng Choo
Institute for Infocomm Research, A*STAR, Singapore, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LFPN AC YSL. Performed the experiments: YJS DJCK FD KHC ZH. Analyzed the data: LFPN AC DJCK LCN EEO KHC ZH. Contributed reagents/materials/analysis tools: LFPN AC PLL FD YSL. Wrote the paper: LFPN AC DJCK KHC PK YSL.