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Research Article

In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection

  • Rachel Lubong Sabado,

    Affiliation: New York University School of Medicine, New York, New York, United States of America

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  • Daniel G. Kavanagh,

    Affiliation: Partners AIDS Research Center (PARC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Daniel E. Kaufmann,

    Affiliation: Partners AIDS Research Center (PARC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Karlhans Fru,

    Affiliation: Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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  • Ethan Babcock,

    Affiliation: New York University School of Medicine, New York, New York, United States of America

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  • Eric Rosenberg,

    Affiliation: Partners AIDS Research Center (PARC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Bruce Walker,

    Affiliation: Partners AIDS Research Center (PARC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Jeffrey Lifson,

    Affiliation: SAIC Fredrick, Inc., National Cancer Institute, Fredrick, Frederick, Maryland, United States of America

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  • Nina Bhardwaj,

    Affiliation: New York University School of Medicine, New York, New York, United States of America

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  • Marie Larsson mail

    marla@imk.liu.se

    Affiliation: Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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  • Published: January 23, 2009
  • DOI: 10.1371/journal.pone.0004256

About the Authors

Rachel Lubong Sabado, Ethan Babcock, Nina Bhardwaj
New York University School of Medicine, New York, New York, United States of America
Daniel G. Kavanagh, Daniel E. Kaufmann, Eric Rosenberg, Bruce Walker
Partners AIDS Research Center (PARC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
Jeffrey Lifson
SAIC Fredrick, Inc., National Cancer Institute, Fredrick, Frederick, Maryland, United States of America
Karlhans Fru, Marie Larsson
Molecular Virology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

Corresponding Author

Email: marla@imk.liu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML. Performed the experiments: RLS DGK DEK KFC EB ML. Analyzed the data: RLS ML. Contributed reagents/materials/analysis tools: ER BDW JDL NB. Wrote the paper: RLS ML. Conceived and designed part of the experiments: DGK DEK. Helped editing the paper: JDL NB.