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Research Article

IL-10 Is Critically Involved in Mycobacterial HSP70 Induced Suppression of Proteoglycan-Induced Arthritis

  • Lotte Wieten equal contributor,

    equal contributor Contributed equally to this work with: Lotte Wieten, Suzanne E. Berlo

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Suzanne E. Berlo equal contributor,

    equal contributor Contributed equally to this work with: Lotte Wieten, Suzanne E. Berlo

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Corlinda B. ten Brink,

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Peter J. van Kooten,

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Mahavir Singh,

    Affiliation: LIONEX Diagnostics & Therapeutics GmbH, Braunschweig, Germany

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  • Ruurd van der Zee,

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Tibor T. Glant,

    Affiliation: Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America

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  • Femke Broere mail,

    f.broere@uu.nl

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Willem van Eden

    Affiliation: Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands

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  • Published: January 14, 2009
  • DOI: 10.1371/journal.pone.0004186

About the Authors

Lotte Wieten, Suzanne E. Berlo, Corlinda B. ten Brink, Peter J. van Kooten, Ruurd van der Zee, Femke Broere, Willem van Eden
Institute of Infectious Diseases and Immunology, Division of Immunology, Utrecht University, Utrecht, the Netherlands
Mahavir Singh
LIONEX Diagnostics & Therapeutics GmbH, Braunschweig, Germany
Tibor T. Glant
Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America

Corresponding Author

Email: f.broere@uu.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LW SEB RvdZ FB WvE. Performed the experiments: LW SEB CBtB PJvK FB. Analyzed the data: LW SEB RvdZ FB WvE. Contributed reagents/materials/analysis tools: MS TTG. Wrote the paper: LW SEB RvdZ FB WvE.