Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

Jason A. Pfister; Chi Ma; Brad E. Morrison; Santosh R. D'Mello

doi:10.1371/journal.pone.0004090

Loading metrics

Open Access

Peer-reviewed

Research Article

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

Jason A. Pfister ,

Contributed equally to this work with: Jason A. Pfister, Chi Ma

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Chi Ma ,

Contributed equally to this work with: Jason A. Pfister, Chi Ma

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Brad E. Morrison,

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America
⨯
Santosh R. D'Mello

* E-mail: dmello@utdallas.edu

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America
⨯

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

Jason A. Pfister,
Chi Ma,
Brad E. Morrison,
Santosh R. D'Mello

Published: December 31, 2008
https://doi.org/10.1371/journal.pone.0004090

About the Authors

Jason A. Pfister

Contributed equally to this work with: Jason A. Pfister, Chi Ma

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America

Chi Ma

Contributed equally to this work with: Jason A. Pfister, Chi Ma

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America

Brad E. Morrison

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America

Santosh R. D'Mello

* E-mail: dmello@utdallas.edu

Affiliation Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAP CM BEM SD. Performed the experiments: JAP CM BEM. Analyzed the data: JAP CM BEM SD. Wrote the paper: BEM SD.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Neuronal death
Is the Subject Area "Neuronal death" applicable to this article?

Thanks for your feedback.
Subcellular localization
Is the Subject Area "Subcellular localization" applicable to this article?

Thanks for your feedback.
Neuropharmacology
Is the Subject Area "Neuropharmacology" applicable to this article?

Thanks for your feedback.
Neuroblastoma cells
Is the Subject Area "Neuroblastoma cells" applicable to this article?

Thanks for your feedback.