About the Authors

Joseph H. Jeong

Contributed equally to this work with: Joseph H. Jeong, Zhenxiong Wang

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Zhenxiong Wang

Contributed equally to this work with: Joseph H. Jeong, Zhenxiong Wang

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Alexander S. Guimaraes

Affiliations Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

Xuesong Ouyang

Affiliation Department of Urology and Pathology, Columbia University College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, New York, United States of America

Jose L. Figueiredo

Affiliations Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America

Zhihu Ding

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Shan Jiang

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Isil Guney

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Gyeong Hoon Kang

Affiliation Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

Eyoung Shin

Affiliation Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

William C. Hahn

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Massimo F. Loda

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Cory Abate-Shen

Affiliation Department of Urology and Pathology, Columbia University College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, New York, New York, United States of America

Ralph Weissleder

Affiliations Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Lynda Chin

lynda_chin@dfci.harvard.edu

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Dermatology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LC. Performed the experiments: JHJ ZW ASG XO JLF ZD SJ IG ES. Analyzed the data: JHJ ZW WCH MFL CAS LC. Contributed reagents/materials/analysis tools: ASG JLF GHK WCH MFL CAS RW. Wrote the paper: JHJ LC.