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Research Article

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

  • Mark Throsby,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merus BV, Utrecht, The Netherlands

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  • Edward van den Brink,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Genmab, Utrecht, The Netherlands

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  • Mandy Jongeneelen,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

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  • Leo L. M. Poon,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China

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  • Philippe Alard,

    Affiliation: Algonomics NV, Gent-Zwijnaarde, Belgium

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  • Lisette Cornelissen,

    Affiliation: Central Veterinary Institute, Wageningen University, Lelystad, The Netherlands

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  • Arjen Bakker,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: AIMM BV, Amsterdam, The Netherlands

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  • Freek Cox,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merus BV, Utrecht, The Netherlands

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  • Els van Deventer,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

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  • Yi Guan,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China

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  • Jindrich Cinatl,

    Affiliation: Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

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  • Jan ter Meulen,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merck Research Laboratories, West Point, Pennsylvania, United States of America

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  • Ignace Lasters,

    Affiliation: Algonomics NV, Gent-Zwijnaarde, Belgium

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  • Rita Carsetti,

    Affiliation: Laboratory of Cell Biology, Bambino Gesu Children's Research Hospital, Rome, Italy

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  • Malik Peiris,

    Affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China

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  • John de Kruif,

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

    Current address: Merus BV, Utrecht, The Netherlands

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  • Jaap Goudsmit mail

    j.goudsmit@crucell.com

    Affiliation: Crucell Holland BV, Leiden, The Netherlands

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  • Published: December 16, 2008
  • DOI: 10.1371/journal.pone.0003942

About the Authors

Mark Throsby, Edward van den Brink, Mandy Jongeneelen, Arjen Bakker, Freek Cox, Els van Deventer, Jan ter Meulen, John de Kruif, Jaap Goudsmit
Crucell Holland BV, Leiden, The Netherlands
Leo L. M. Poon, Yi Guan, Malik Peiris
Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China
Philippe Alard, Ignace Lasters
Algonomics NV, Gent-Zwijnaarde, Belgium
Lisette Cornelissen
Central Veterinary Institute, Wageningen University, Lelystad, The Netherlands
Jindrich Cinatl
Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Rita Carsetti
Laboratory of Cell Biology, Bambino Gesu Children's Research Hospital, Rome, Italy

Corresponding Author

Email: j.goudsmit@crucell.com

Competing Interests

MT., EvdB, MJ, AB, FC, ED, JtM., JdK. and JG are employees of Crucell Holland BV. PA and IL are employees of Algonomics NV.

Author Contributions

Conceived and designed the experiments: MT EvdB LLMP LC JtM RC JSMP JdK. Performed the experiments: EvdB MJ PA AB FC EvD. Analyzed the data: MT EvdB LLMP PA LC AB FC EvD JtM IL JSMP JdK JG. Contributed reagents/materials/analysis tools: YG JC RC. Wrote the paper: MT JG.