About the Authors

Magdalini Polymenidou

Current address: Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California, United States of America

Affiliation Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland

Rita Moos

Affiliation Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland

Mike Scott

Current address: Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America

Affiliation Functional Genomics Center Zurich, ETH/University of Zürich, Zürich, Switzerland

Christina Sigurdson

Current address: Institute of Pathology, University of California San Diego, La Jolla, California, United States of America

Affiliation Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland

Yong-zhong Shi

Affiliation Alberta Research Council, Edmonton, Alberta, Canada

Bill Yajima

Affiliation Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada

Iva Hafner-Bratkovič

Affiliation Department of Biotechnology, National Institute of Chemistry, University of Ljubljana, Ljubljana, Slovenia

Roman Jerala

Affiliations Department of Biotechnology, National Institute of Chemistry, University of Ljubljana, Ljubljana, Slovenia, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia

Simone Hornemann

Affiliation Institut für Molekularbiologie und Biophysik, ETH Zürich, Zürich, Switzerland

Kurt Wuthrich

Affiliations Institut für Molekularbiologie und Biophysik, ETH Zürich, Zürich, Switzerland, Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

Anne Bellon

Affiliation ZLB Behring, Marburg, Germany

Martin Vey

Affiliation ZLB Behring, Marburg, Germany

Graciela Garen

Affiliations Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Michael N. G. James

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Nat Kav

Affiliation Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada

Adriano Aguzzi

adriano.aguzzi@usz.ch

Affiliation Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MP NK AA. Performed the experiments: MP RM MS CS BY AB MV. Analyzed the data: MP. Contributed reagents/materials/analysis tools: YzS IHB RJ SH KW GG MJ. Wrote the paper: MP.