VHL Type 2B Mutations Retain VBC Complex Form and Function

Kathryn E. Hacker; Caroline Martz Lee; W. Kimryn Rathmell

doi:10.1371/journal.pone.0003801

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Open Access

Peer-reviewed

Research Article

VHL Type 2B Mutations Retain VBC Complex Form and Function

Kathryn E. Hacker,

Affiliation Department of Medicine, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Durham, North Carolina, United States of America
⨯
Caroline Martz Lee,

Affiliation Department of Medicine, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Durham, North Carolina, United States of America
⨯
W. Kimryn Rathmell

* E-mail: Rathmell@med.unc.edu

Affiliation Department of Medicine, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Durham, North Carolina, United States of America
⨯

VHL Type 2B Mutations Retain VBC Complex Form and Function

Kathryn E. Hacker,
Caroline Martz Lee,
W. Kimryn Rathmell

Published: November 25, 2008
https://doi.org/10.1371/journal.pone.0003801

About the Authors

Kathryn E. Hacker

Affiliation Department of Medicine, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Durham, North Carolina, United States of America

Caroline Martz Lee

W. Kimryn Rathmell

* E-mail: Rathmell@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KEH CML WKR. Performed the experiments: KEH CML. Analyzed the data: KEH CML WKR. Contributed reagents/materials/analysis tools: WKR. Wrote the paper: KEH WKR.

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Immunoblotting
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Renal cancer
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Renal cell carcinoma
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Cloning
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Hypoxia
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Protein interactions
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Cancer risk factors
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Missense mutation
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