Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

Gwen Liu; Hyeyoung Min; Sibiao Yue; Chang-Zheng Chen

doi:10.1371/journal.pone.0003592

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Open Access

Peer-reviewed

Research Article

Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

Gwen Liu ,

Contributed equally to this work with: Gwen Liu, Hyeyoung Min

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Hyeyoung Min ,

Contributed equally to this work with: Gwen Liu, Hyeyoung Min

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Sibiao Yue,

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Chang-Zheng Chen

* E-mail: czchen@stanford.edu

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America
⨯

Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

Gwen Liu,
Hyeyoung Min,
Sibiao Yue,
Chang-Zheng Chen

Published: October 31, 2008
https://doi.org/10.1371/journal.pone.0003592

About the Authors

Gwen Liu

Contributed equally to this work with: Gwen Liu, Hyeyoung Min

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America

Hyeyoung Min

Contributed equally to this work with: Gwen Liu, Hyeyoung Min

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America

Sibiao Yue

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America

Chang-Zheng Chen

* E-mail: czchen@stanford.edu

Affiliation Department of Microbiology and Immunology, Baxter Laboratory of Genetic Pharmacology, Stanford University School of Medicine, Stanford, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GL HM CZC. Performed the experiments: GL HM SY. Analyzed the data: GL HM SY CZC. Contributed reagents/materials/analysis tools: GL HM SY CZC. Wrote the paper: GL HM SY CZC.

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MicroRNAs
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Nucleotides
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Transfection
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T cells
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Mutant genes
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Northern blot
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Nucleotide sequencing
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Thymocytes
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