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Research Article

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

  • Davide Lecca equal contributor,

    equal contributor Contributed equally to this work with: Davide Lecca, Maria Letizia Trincavelli, Paolo Gelosa, Mauro Cimino, Maria P. Abbracchio

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Maria Letizia Trincavelli equal contributor,

    equal contributor Contributed equally to this work with: Davide Lecca, Maria Letizia Trincavelli, Paolo Gelosa, Mauro Cimino, Maria P. Abbracchio

    Affiliation: Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy

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  • Paolo Gelosa equal contributor,

    equal contributor Contributed equally to this work with: Davide Lecca, Maria Letizia Trincavelli, Paolo Gelosa, Mauro Cimino, Maria P. Abbracchio

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Luigi Sironi,

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Paolo Ciana,

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Marta Fumagalli,

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Giovanni Villa,

    Affiliations: Department of Pharmacological Sciences, University of Milan, Milan, Italy, Centro Neurolesi “Bonino-Pulejo” IRCCS, Messina, Italy

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  • Claudia Verderio,

    Affiliation: CNR Institute of Neuroscience, University of Milan, Milan, Italy

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  • Carlotta Grumelli,

    Affiliation: CNR Institute of Neuroscience, University of Milan, Milan, Italy

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  • Uliano Guerrini,

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Elena Tremoli,

    Affiliations: Department of Pharmacological Sciences, University of Milan, Milan, Italy, Monzino Cardiologic Center IRCCS, Milan, Italy

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  • Patrizia Rosa,

    Affiliation: CNR Institute of Neuroscience, University of Milan, Milan, Italy

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  • Serena Cuboni,

    Affiliation: Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy

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  • Claudia Martini,

    Affiliation: Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy

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  • Annalisa Buffo,

    Affiliation: Department of Neuroscience, University of Turin, Turin, Italy

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  • Mauro Cimino equal contributor,

    equal contributor Contributed equally to this work with: Davide Lecca, Maria Letizia Trincavelli, Paolo Gelosa, Mauro Cimino, Maria P. Abbracchio

    Affiliation: Institute of Pharmacology and Pharmacognosy, University of Urbino, Urbino, Italy

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  • Maria P. Abbracchio equal contributor mail

    equal contributor Contributed equally to this work with: Davide Lecca, Maria Letizia Trincavelli, Paolo Gelosa, Mauro Cimino, Maria P. Abbracchio

    mariapia.abbracchio@unimi.it

    Affiliation: Department of Pharmacological Sciences, University of Milan, Milan, Italy

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  • Published: October 31, 2008
  • DOI: 10.1371/journal.pone.0003579

About the Authors

Davide Lecca, Paolo Gelosa, Luigi Sironi, Paolo Ciana, Marta Fumagalli, Giovanni Villa, Uliano Guerrini, Elena Tremoli, Maria P. Abbracchio
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Maria Letizia Trincavelli, Serena Cuboni, Claudia Martini
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Giovanni Villa
Centro Neurolesi “Bonino-Pulejo” IRCCS, Messina, Italy
Claudia Verderio, Carlotta Grumelli, Patrizia Rosa
CNR Institute of Neuroscience, University of Milan, Milan, Italy
Elena Tremoli
Monzino Cardiologic Center IRCCS, Milan, Italy
Annalisa Buffo
Department of Neuroscience, University of Turin, Turin, Italy
Mauro Cimino
Institute of Pharmacology and Pharmacognosy, University of Urbino, Urbino, Italy

Corresponding Author

Email: mariapia.abbracchio@unimi.it

Competing Interests

MLT, PC, CV, CM and MPA are inventors in the Italian Patent Application #2004A002007 on “Modulatori del recettore GPR17 e loro impieghi terapeutici” submitted on October 21, 2004.

Author Contributions

Conceived and designed the experiments: DL MLT PG LS MF CV PR CM AB MC MPA. Performed the experiments: DL MLT PG MF GV CG PR SC AB MC. Analyzed the data: DL MLT PG LS MF GV CV PR AB MC MPA. Contributed reagents/materials/analysis tools: MLT LS PC CV CG UG ET PR SC CM. Wrote the paper: DL AB MC MPA.