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Research Article

Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

  • Fernando E. Herrera equal contributor,

    equal contributor Contributed equally to this work with: Fernando E. Herrera, Alessandra Chesi

    Affiliations: International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy, Italian Institute of Technology- SISSA Unit, Trieste, Italy

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  • Alessandra Chesi equal contributor,

    equal contributor Contributed equally to this work with: Fernando E. Herrera, Alessandra Chesi

    Affiliations: Italian Institute of Technology- SISSA Unit, Trieste, Italy, Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy, The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy

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  • Katerina E. Paleologou,

    Affiliation: Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Adrian Schmid,

    Affiliation: Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Adriana Munoz,

    Affiliations: International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy, Italian Institute of Technology- SISSA Unit, Trieste, Italy, Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy, The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy

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  • Michele Vendruscolo,

    Affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom

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  • Stefano Gustincich mail,

    gustinci@sissa.it (SG); carloni@sissa.it (PC)

    Affiliations: Italian Institute of Technology- SISSA Unit, Trieste, Italy, Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy, The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy

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  • Hilal A. Lashuel,

    Affiliation: Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

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  • Paolo Carloni mail

    gustinci@sissa.it (SG); carloni@sissa.it (PC)

    Affiliations: International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy, Italian Institute of Technology- SISSA Unit, Trieste, Italy

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  • Published: October 14, 2008
  • DOI: 10.1371/journal.pone.0003394

About the Authors

Fernando E. Herrera, Adriana Munoz, Paolo Carloni
International School for Advanced Studies (SISSA), INFM DEMOCRITOS, Trieste, Italy
Fernando E. Herrera, Alessandra Chesi, Adriana Munoz, Stefano Gustincich, Paolo Carloni
Italian Institute of Technology- SISSA Unit, Trieste, Italy
Alessandra Chesi, Adriana Munoz, Stefano Gustincich
Sector of Neurobiology, International School for Advanced Studies (SISSA), Basovizza, Trieste, Italy
Alessandra Chesi, Adriana Munoz, Stefano Gustincich
The Giovanni Armenise-Harvard Foundation Laboratory, Sector of Neurobiology, International School for Advanced Studies (SISSA), AREA Science Park, Trieste, Italy
Katerina E. Paleologou, Adrian Schmid, Hilal A. Lashuel
Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland
Michele Vendruscolo
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FEH AC KEP AS SG HL PC. Performed the experiments: FEH AC AM. Analyzed the data: FEH AC. Contributed reagents/materials/analysis tools: KEP AS MV HL. Wrote the paper: FEH AC MV SG HL PC.