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Research Article

Evolution of the Aging Brain Transcriptome and Synaptic Regulation

  • Patrick M. Loerch equal contributor,

    equal contributor Contributed equally to this work with: Patrick M. Loerch, Tao Lu

    Affiliations: Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biostatistics, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Tao Lu equal contributor,

    equal contributor Contributed equally to this work with: Patrick M. Loerch, Tao Lu

    Affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Kelly A. Dakin,

    Affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • James M. Vann,

    Affiliation: Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Adrian Isaacs,

    Affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Chengiz Geula,

    Affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois, United States of America

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  • Jianbin Wang,

    Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ying Pan,

    Affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Dana H. Gabuzda,

    Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Cheng Li,

    Affiliation: Department of Biostatistics, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Tomas A. Prolla,

    Affiliation: Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

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  • Bruce A. Yankner mail

    bruce_yankner@hms.harvard.edu

    Affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: October 02, 2008
  • DOI: 10.1371/journal.pone.0003329

About the Authors

Patrick M. Loerch, Tao Lu, Kelly A. Dakin, Adrian Isaacs, Ying Pan, Bruce A. Yankner
Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
James M. Vann, Tomas A. Prolla
Department of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
Chengiz Geula
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, Illinois, United States of America
Jianbin Wang, Dana H. Gabuzda
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
Patrick M. Loerch, Cheng Li
Department of Biostatistics, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts, United States of America

Corresponding Author

Email: bruce_yankner@hms.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TL BAY. Performed the experiments: TL KAD JMV AMI YP. Analyzed the data: PML TL CL BAY. Contributed reagents/materials/analysis tools: JMV AMI CG JW DG TAP. Wrote the paper: PML BAY.