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Research Article

Herpes-Virus Infection in Patients with Langerhans Cell Histiocytosis: A Case-Controlled Sero-Epidemiological Study, and In Situ Analysis

  • Eric Jeziorski equal contributor,

    equal contributor Contributed equally to this work with: Eric Jeziorski, Brigitte Senechal

    Affiliation: Laboratory of biology of the mononuclear phagocyte system, INSERM U838, University Paris-Descartes, Paris, France

    X
  • Brigitte Senechal equal contributor,

    equal contributor Contributed equally to this work with: Eric Jeziorski, Brigitte Senechal

    Affiliation: Laboratory of biology of the mononuclear phagocyte system, INSERM U838, University Paris-Descartes, Paris, France

    X
  • Thierry Jo Molina,

    Affiliations: Laboratory of biology of the mononuclear phagocyte system, INSERM U838, University Paris-Descartes, Paris, France, Hopital de l'Hotel Dieu, Pathology department, AP-HP, Paris, France

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  • Francis Devez,

    Affiliation: Hopital de l'Hotel Dieu, Pathology department, AP-HP, Paris, France

    X
  • Marianne Leruez-Ville,

    Affiliation: Hopital Necker-Enfants Malades, AP-HP, Paris, France

    X
  • Patrice Morand,

    Affiliation: Centre Hospitalo-Universitaire Michallon, Virology department, Grenoble, France

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  • Christophe Glorion,

    Affiliation: Hopital Necker-Enfants Malades, AP-HP, Paris, France

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  • Ludovic Mansuy,

    Affiliation: Centre Hospitalo-Universitaire de Nancy, Medecine infantile II, Nancy, France

    X
  • Joel Gaudelus,

    Affiliation: Hopital Jean Verdier, AP-HP, service de Pediatrie, Bondy, France

    X
  • Marianne Debre,

    Affiliation: Hopital Necker-Enfants Malades, AP-HP, Paris, France

    X
  • Francis Jaubert,

    Affiliations: Laboratory of biology of the mononuclear phagocyte system, INSERM U838, University Paris-Descartes, Paris, France, Hopital Necker-Enfants Malades, AP-HP, Paris, France

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  • Jean-Marie Seigneurin,

    Affiliation: Centre Hospitalo-Universitaire Michallon, Virology department, Grenoble, France

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  • Caroline Thomas,

    Affiliation: Centre Hospitalo-Universitaire de Nantes, Pediatrie, Nantes, France

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  • Irene Joab,

    Affiliation: UMR542 Inserm-Universite Paris Sud, Hopital Paul Brousse, Villejuif, France

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  • Jean Donadieu,

    Affiliation: Hopital d'Enfants Armand Trousseau, Pediatric Hematology unit, Centre de référence de l'histiocytose AP-HP, Paris, France

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  • Frederic Geissmann mail

    geissmann@kcl.ac.uk

    Affiliations: Laboratory of biology of the mononuclear phagocyte system, INSERM U838, University Paris-Descartes, Paris, France, Hopital Necker-Enfants Malades, AP-HP, Paris, France

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  • Published: September 23, 2008
  • DOI: 10.1371/journal.pone.0003262

About the Authors

Eric Jeziorski, Brigitte Senechal, Thierry Jo Molina, Francis Jaubert, Frederic Geissmann
Laboratory of biology of the mononuclear phagocyte system, INSERM U838, University Paris-Descartes, Paris, France
Thierry Jo Molina, Francis Devez
Hopital de l'Hotel Dieu, Pathology department, AP-HP, Paris, France
Marianne Leruez-Ville, Christophe Glorion, Marianne Debre, Francis Jaubert, Frederic Geissmann
Hopital Necker-Enfants Malades, AP-HP, Paris, France
Patrice Morand, Jean-Marie Seigneurin
Centre Hospitalo-Universitaire Michallon, Virology department, Grenoble, France
Ludovic Mansuy
Centre Hospitalo-Universitaire de Nancy, Medecine infantile II, Nancy, France
Joel Gaudelus
Hopital Jean Verdier, AP-HP, service de Pediatrie, Bondy, France
Caroline Thomas
Centre Hospitalo-Universitaire de Nantes, Pediatrie, Nantes, France
Irene Joab
UMR542 Inserm-Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
Jean Donadieu
Hopital d'Enfants Armand Trousseau, Pediatric Hematology unit, Centre de référence de l'histiocytose AP-HP, Paris, France

Corresponding Author

Email: geissmann@kcl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BS TM JD FG. Performed the experiments: EJ BS FD MLV. Analyzed the data: EJ BS TM MLV IJ JD FG. Contributed reagents/materials/analysis tools: TM PM CG LM JG MD FJ JMS CT IJ. Wrote the paper: BS JD FG.