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Research Article

Simplivariate Models: Ideas and First Examples

  • Jos A. Hageman,

    Affiliations: Biosystems Data Analysis, Universiteit van Amsterdam, Amsterdam, The Netherlands, ABC Metabolomics Centre, Lab. Metabolic and Endocrine Diseases, Wilhelmina Children's Hospital, Utrecht, The Netherlands

    Current address: Biometris, Wageningen University, Wageningen, The Netherlands

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  • Margriet M. W. B. Hendriks,

    Affiliation: ABC Metabolomics Centre, Lab. Metabolic and Endocrine Diseases, Wilhelmina Children's Hospital, Utrecht, The Netherlands

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  • Johan A. Westerhuis mail,

    j.a.westerhuis@uva.nl

    Affiliation: Biosystems Data Analysis, Universiteit van Amsterdam, Amsterdam, The Netherlands

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  • Mariët J. van der Werf,

    Affiliation: TNO Quality of Life, Zeist, The Netherlands

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  • Ruud Berger,

    Affiliation: ABC Metabolomics Centre, Lab. Metabolic and Endocrine Diseases, Wilhelmina Children's Hospital, Utrecht, The Netherlands

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  • Age K. Smilde

    Affiliations: Biosystems Data Analysis, Universiteit van Amsterdam, Amsterdam, The Netherlands, TNO Quality of Life, Zeist, The Netherlands

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  • Published: September 23, 2008
  • DOI: 10.1371/journal.pone.0003259

About the Authors

Jos A. Hageman, Johan A. Westerhuis, Age K. Smilde
Biosystems Data Analysis, Universiteit van Amsterdam, Amsterdam, The Netherlands
Jos A. Hageman, Margriet M. W. B. Hendriks, Ruud Berger
ABC Metabolomics Centre, Lab. Metabolic and Endocrine Diseases, Wilhelmina Children's Hospital, Utrecht, The Netherlands
Mariët J. van der Werf, Age K. Smilde
TNO Quality of Life, Zeist, The Netherlands

Corresponding Author

Email: j.a.westerhuis@uva.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAH MMWBH JAW AS. Performed the experiments: MJvdW. Analyzed the data: JAH. Contributed reagents/materials/analysis tools: MJvdW. Wrote the paper: JAH MMWBH JAW AS. Group Leader: AS RB MJvdW.