Advertisement
Research Article

Imaging Mass Spectrometry Technology and Application on Ganglioside Study; Visualization of Age-Dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus

  • Yuki Sugiura,

    Affiliations: Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan

    X
  • Shuichi Shimma,

    Affiliation: National Institute for Physiological Sciences, Okazaki, Aichi, Japan

    Current address: Renovation Center of Instruments for Science Education and Technology, Osaka University, Toyonaka, Osaka, Japan

    X
  • Yoshiyuki Konishi,

    Affiliation: Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan

    X
  • Maki K. Yamada,

    Affiliation: Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan

    X
  • Mitsutoshi Setou mail

    setou@hama-med.ac.jp

    Affiliations: Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan, Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan, National Institute for Physiological Sciences, Okazaki, Aichi, Japan, Hamamatsu Medical School, Department of Molecular Anatomy, Hamamatsu, Shizuoka, Japan

    X
  • Published: September 18, 2008
  • DOI: 10.1371/journal.pone.0003232

About the Authors

Yuki Sugiura, Mitsutoshi Setou
Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan
Yuki Sugiura, Yoshiyuki Konishi, Maki K. Yamada, Mitsutoshi Setou
Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo, Japan
Shuichi Shimma, Mitsutoshi Setou
National Institute for Physiological Sciences, Okazaki, Aichi, Japan
Mitsutoshi Setou
Hamamatsu Medical School, Department of Molecular Anatomy, Hamamatsu, Shizuoka, Japan

Corresponding Author

Email: setou@hama-med.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YS SS YK. Performed the experiments: YS SS. Analyzed the data: YS SS. Wrote the paper: YS SS YK MKY MS.