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Research Article

The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

  • Maninder K. Sohi,

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Dennis A. Veselkov,

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Ivan Laponogov,

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Xiao-Su Pan,

    Affiliation: Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London, United Kingdom

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  • L. Mark Fisher mail,

    lfisher@sgul.ac.uk (LMF); mark.sanderson@kcl.ac.uk (MRS)

    Affiliation: Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London, United Kingdom

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  • Mark R. Sanderson mail

    lfisher@sgul.ac.uk (LMF); mark.sanderson@kcl.ac.uk (MRS)

    Affiliation: Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

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  • Published: September 12, 2008
  • DOI: 10.1371/journal.pone.0003201

About the Authors

Maninder K. Sohi, Dennis A. Veselkov, Ivan Laponogov, Mark R. Sanderson
Randall Division of Cell and Molecular Biophysics, School of Biomedical and Health Sciences, King's College London, London, United Kingdom
Xiao-Su Pan, L. Mark Fisher
Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London, United Kingdom

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MKS DAV IL XSP LMF MRS. Performed the experiments: MKS DAV IL XSP MRS. Analyzed the data: MKS DAV IL XSP MRS. Contributed reagents/materials/analysis tools: MKS XSP LMF. Wrote the paper: MKS DAV IL XSP LMF MRS.