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Research Article

Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity

  • Stuart G. Turville,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

    Current address: Center for Virus Research, Westmead Millennium Institute, Westmead Hospital and University of Sydney, Sydney, Australia

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  • Meropi Aravantinou,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Todd Miller,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Jessica Kenney,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Aaron Teitelbaum,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Lieyu Hu,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Anne Chudolij,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Tom M. Zydowsky,

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Michael Piatak Jr,

    Affiliation: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, United States of America

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  • Julian W. Bess Jr,

    Affiliation: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, United States of America

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  • Jeffrey D. Lifson,

    Affiliation: AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, United States of America

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  • James Blanchard,

    Affiliation: Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America

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  • Agegnehu Gettie,

    Affiliation: Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America

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  • Melissa Robbiani mail

    mrobbiani@popcouncil.org

    Affiliation: Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America

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  • Published: September 08, 2008
  • DOI: 10.1371/journal.pone.0003162

About the Authors

Stuart G. Turville, Meropi Aravantinou, Todd Miller, Jessica Kenney, Aaron Teitelbaum, Lieyu Hu, Anne Chudolij, Tom M. Zydowsky, Melissa Robbiani
Center for Biomedical Research, HIV and AIDS Program, Population Council, New York, New York, United States of America
Michael Piatak Jr, Julian W. Bess Jr, Jeffrey D. Lifson
AIDS and Cancer Virus Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, United States of America
James Blanchard
Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America
Agegnehu Gettie
Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, United States of America

Corresponding Author

Email: mrobbiani@popcouncil.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SGT MR. Performed the experiments: SGT MA TM JK AT LH AC TZ MPJ JWB JB AG. Analyzed the data: SGT MA TM JK MPJ JWB JDL AG MR. Contributed reagents/materials/analysis tools: AT LH AC TZ MPJ JWB JDL JB AG. Wrote the paper: SGT MR. Significant editing of manuscript: JDL.