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Research Article

Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study

  • Mady Hornig mail,

    mady.hornig@columbia.edu (MH); wil2001@columbia.edu (WIL)

    Affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

    X
  • Thomas Briese,

    Affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

    X
  • Timothy Buie,

    Affiliation: Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Margaret L. Bauman,

    Affiliation: Department of Neurology, Harvard Medical School and Departments of Neurology and Pediatrics and Learning and Developmental Disabilities Evaluation and Rehabilitation Services (LADDERS), Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Gregory Lauwers,

    Affiliation: Department of Pathology of Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America

    X
  • Ulrike Siemetzki,

    Affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

    X
  • Kimberly Hummel,

    Affiliation: Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Paul A. Rota,

    Affiliation: Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • William J. Bellini,

    Affiliation: Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • John J. O'Leary,

    Affiliation: Department of Histopathology, Trinity College Dublin, Dublin, Ireland

    X
  • Orla Sheils,

    Affiliation: Department of Histopathology, Trinity College Dublin, Dublin, Ireland

    X
  • Errol Alden,

    Affiliation: American Academy of Pediatrics, Elk Grove Village, Illinois, United States of America

    X
  • Larry Pickering,

    Affiliation: National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • W. Ian Lipkin mail

    mady.hornig@columbia.edu (MH); wil2001@columbia.edu (WIL)

    Affiliation: Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America

    X
  • Published: September 04, 2008
  • DOI: 10.1371/journal.pone.0003140

About the Authors

Mady Hornig, Thomas Briese, Ulrike Siemetzki, W. Ian Lipkin
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America
Timothy Buie
Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Margaret L. Bauman
Department of Neurology, Harvard Medical School and Departments of Neurology and Pediatrics and Learning and Developmental Disabilities Evaluation and Rehabilitation Services (LADDERS), Massachusetts General Hospital, Boston, Massachusetts, United States of America
Gregory Lauwers
Department of Pathology of Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
Kimberly Hummel, Paul A. Rota, William J. Bellini
Measles, Mumps, Rubella, and Herpesvirus Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
John J. O'Leary, Orla Sheils
Department of Histopathology, Trinity College Dublin, Dublin, Ireland
Errol Alden
American Academy of Pediatrics, Elk Grove Village, Illinois, United States of America
Larry Pickering
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Corresponding Authors

Competing Interests

Authors JOL and OS were compensated for expert witness statements concerning MMR vaccine and autism on behalf of claimants in litigation in the United Kingdom.

Author Contributions

Conceived and designed the experiments: MH TB LP WIL. Performed the experiments: TB TB MB GL US KH OS. Analyzed the data: MH TB MB GL WIL. Contributed reagents/materials/analysis tools: TB TB GL PAR WJB JO. Wrote the paper: MH WIL. Obtained funding: WIL MH EA. Study supervision: WIL MB TB MH TB. Critical revisions of manuscript: WIL MH TB LP OS JO WJB PAR KH MB. Statistical analysis: MH. Study oversight: LP.