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Research Article

Multiple Advantageous Amino Acid Variants in the NAT2 Gene in Human Populations

  • Francesca Luca,

    Affiliation: Department of Cell Biology, University of Calabria, Rende, Italy

    Current address: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

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  • Giuseppina Bubba,

    Affiliation: Department of Cell Biology, University of Calabria, Rende, Italy

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  • Massimo Basile,

    Affiliation: Department of Cell Biology, University of Calabria, Rende, Italy

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  • Radim Brdicka,

    Affiliation: Institute for Haematology and Blood Transfusion, Prague, Czech Republic

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  • Emmanuel Michalodimitrakis,

    Affiliation: Institute of Molecular Biology and Biotechnology, Heraklion, Greece

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  • Olga Rickards,

    Affiliation: Department of Biology, University “Tor Vergata”, Rome, Italy

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  • Galina Vershubsky,

    Affiliations: Arct. An. C Innovative Laboratory, Moscow, Russia, Institute of Developmental Physiology, Russian Academy of Education, Moscow, Russia

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  • Lluis Quintana-Murci,

    Affiliation: UP Human Evolutionary Genetics, CNRS-URA3012, Institut Pasteur, Paris, France

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  • Andrey I. Kozlov,

    Affiliation: Arct. An. C Innovative Laboratory, Moscow, Russia

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  • Andrea Novelletto mail

    novelletto@bio.uniroma2.it

    Affiliations: Department of Cell Biology, University of Calabria, Rende, Italy, Department of Biology, University “Tor Vergata”, Rome, Italy

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  • Published: September 05, 2008
  • DOI: 10.1371/journal.pone.0003136

About the Authors

Francesca Luca, Giuseppina Bubba, Massimo Basile, Andrea Novelletto
Department of Cell Biology, University of Calabria, Rende, Italy
Radim Brdicka
Institute for Haematology and Blood Transfusion, Prague, Czech Republic
Emmanuel Michalodimitrakis
Institute of Molecular Biology and Biotechnology, Heraklion, Greece
Olga Rickards, Andrea Novelletto
Department of Biology, University “Tor Vergata”, Rome, Italy
Galina Vershubsky, Andrey I. Kozlov
Arct. An. C Innovative Laboratory, Moscow, Russia
Galina Vershubsky
Institute of Developmental Physiology, Russian Academy of Education, Moscow, Russia
Lluis Quintana-Murci
UP Human Evolutionary Genetics, CNRS-URA3012, Institut Pasteur, Paris, France

Corresponding Author

Email: novelletto@bio.uniroma2.it

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FL LQM AK AN. Performed the experiments: FL GB. Analyzed the data: FL MB AN. Wrote the paper: FL RB EM OR GV LQM AK AN. Senior author: AK. Collected DNA samples and nutritional information: AK GV OR EM RB AN.