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Research Article

Duplication and Diversification of the Hypoxia-Inducible IGFBP-1 Gene in Zebrafish

  • Hiroyasu Kamei,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Ling Lu,

    Affiliation: Laboratory of Molecular Medicine, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China

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  • Shuang Jiao,

    Affiliation: Laboratory of Molecular Medicine, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China

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  • Yun Li,

    Affiliation: Laboratory of Molecular Medicine, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China

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  • Claus Gyrup,

    Affiliation: Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark

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  • Lisbeth S. Laursen,

    Affiliation: Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark

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  • Claus Oxvig,

    Affiliation: Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark

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  • Jianfeng Zhou,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Cunming Duan mail

    cduan@umich.edu

    Affiliations: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America, Laboratory of Molecular Medicine, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China

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  • Published: August 28, 2008
  • DOI: 10.1371/journal.pone.0003091

About the Authors

Hiroyasu Kamei, Jianfeng Zhou, Cunming Duan
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
Ling Lu, Shuang Jiao, Yun Li, Cunming Duan
Laboratory of Molecular Medicine, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
Claus Gyrup, Lisbeth S. Laursen, Claus Oxvig
Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark

Corresponding Author

Email: cduan@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HK CD. Performed the experiments: HK LL SJ LL JZ. Analyzed the data: HK LL SJ YL LL CO JZ CD. Contributed reagents/materials/analysis tools: YL CO CD. Wrote the paper: HK CD.