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Research Article

Stochasticity and the Molecular Mechanisms of Induced Pluripotency

  • Ben D. MacArthur mail,

    bdm@soton.ac.uk

    Affiliations: Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Developmental Origins of Health and Disease, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom, School of Mathematics, University of Southampton, Southampton, United Kingdom

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  • Colin P. Please,

    Affiliation: School of Mathematics, University of Southampton, Southampton, United Kingdom

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  • Richard O. C. Oreffo

    Affiliation: Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Developmental Origins of Health and Disease, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom

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  • Published: August 28, 2008
  • DOI: 10.1371/journal.pone.0003086

About the Authors

Ben D. MacArthur, Richard O. C. Oreffo
Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Developmental Origins of Health and Disease, Institute of Developmental Sciences, University of Southampton, Southampton, United Kingdom
Ben D. MacArthur, Colin P. Please
School of Mathematics, University of Southampton, Southampton, United Kingdom

Corresponding Author

Email: bdm@soton.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BDM. Analyzed the data: BDM CPP ROO. Wrote the paper: BDM. Helped write the paper: CPP ROCO. Oversaw the project: ROCO. Conceived, designed and analyzed the mathematical model: BDM.