About the Authors

Qing-Bai She

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Sarat Chandarlapaty

Contributed equally to this work with: Sarat Chandarlapaty, Qing Ye

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Qing Ye

Contributed equally to this work with: Sarat Chandarlapaty, Qing Ye

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Jose Lobo

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Kathleen M. Haskell

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Karen R. Leander

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Deborah DeFeo-Jones

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Hans E. Huber

Affiliation Department of Cancer Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Neal Rosen

rosenn@mskcc.org

Affiliation Program in Molecular Pharmacology and Chemistry and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Competing Interests

KMH, KRL and HEH are employees of Merck & Co. Inc. DDJ is an employee of GlaxoSmithKline Co. KMH, KRL, DDJ and HEH own Merck stock and stock options. KMH, DDJ and HEH are inventors on a patent application related to Akt inhibitors. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: QBS NR. Performed the experiments: QBS SC QY JL. Analyzed the data: QBS SC QY JL DDJ HEH NR. Contributed reagents/materials/analysis tools: KMH KRL DDJ HEH. Wrote the paper: QBS NR.