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Research Article

I–II Loop Structural Determinants in the Gating and Surface Expression of Low Voltage-Activated Calcium Channels

  • Joel P. Baumgart,

    Affiliations: Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America, Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, United States of America

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  • Iuliia Vitko,

    Affiliation: Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America

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  • Isabelle Bidaud,

    Affiliations: CNRS, UMR 5203, Institut de Génomique fonctionnelle, Montpellier, France, INSERM, U661, Montpellier, France, Université Montpellier, 1 et 2, Montpellier, France

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  • Artem Kondratskyi,

    Affiliation: Department of General Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine

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  • Philippe Lory,

    Affiliations: CNRS, UMR 5203, Institut de Génomique fonctionnelle, Montpellier, France, INSERM, U661, Montpellier, France, Université Montpellier, 1 et 2, Montpellier, France

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  • Edward Perez-Reyes mail

    eperez@virginia.edu

    Affiliations: Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America, Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, United States of America

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  • Published: August 20, 2008
  • DOI: 10.1371/journal.pone.0002976

About the Authors

Joel P. Baumgart, Iuliia Vitko, Edward Perez-Reyes
Department of Pharmacology, University of Virginia, Charlottesville, Virginia, United States of America
Joel P. Baumgart, Edward Perez-Reyes
Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, United States of America
Isabelle Bidaud, Philippe Lory
CNRS, UMR 5203, Institut de Génomique fonctionnelle, Montpellier, France
Isabelle Bidaud, Philippe Lory
INSERM, U661, Montpellier, France
Isabelle Bidaud, Philippe Lory
Université Montpellier, 1 et 2, Montpellier, France
Artem Kondratskyi
Department of General Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine

Corresponding Author

Email: eperez@virginia.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPB PL EPR. Performed the experiments: JPB IV IB AK. Analyzed the data: JPB IB PL EPR. Contributed reagents/materials/analysis tools: IV AK. Wrote the paper: JPB PL EPR. Obtained funding: JPB PL EPR.