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Research Article

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

  • Adriano Boasso mail,

    a.boasso@imperial.ac.uk

    Affiliations: Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America, Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom

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  • Andrew W. Hardy,

    Affiliation: Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

    Current address: Vitae Pharmaceuticals, Ft. Washington, Pennsylvania, United States of America

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  • Stephanie A. Anderson,

    Affiliation: Henry M. Jackson Foundation, Infectious Disease Clinical Research Program (IDCRP), Wilford Hall Medical Center, Lackland Air Force Base, Texas, United States of America

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  • Matthew J. Dolan,

    Affiliation: Henry M. Jackson Foundation, Infectious Disease Clinical research Program (IDCRP), San Antonio Military Medical Center (SAMMC), Fort Sam Houston, Texas, United States of America

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  • Gene M. Shearer

    Affiliation: Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

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  • Published: August 13, 2008
  • DOI: 10.1371/journal.pone.0002961

About the Authors

Adriano Boasso, Andrew W. Hardy, Gene M. Shearer
Experimental Immunology Branch, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America
Adriano Boasso
Department of Immunology, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital, London, United Kingdom
Stephanie A. Anderson
Henry M. Jackson Foundation, Infectious Disease Clinical Research Program (IDCRP), Wilford Hall Medical Center, Lackland Air Force Base, Texas, United States of America
Matthew J. Dolan
Henry M. Jackson Foundation, Infectious Disease Clinical research Program (IDCRP), San Antonio Military Medical Center (SAMMC), Fort Sam Houston, Texas, United States of America

Corresponding Author

Email: a.boasso@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AB GMS. Performed the experiments: AB AWH. Analyzed the data: AB GMS. Contributed reagents/materials/analysis tools: SAA MJD. Wrote the paper: AB GMS.