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Research Article

Pre-Clinical Evaluation of a Novel Nanoemulsion-Based Hepatitis B Mucosal Vaccine

  • Paul E. Makidon equal contributor,

    equal contributor Contributed equally to this work with: Paul E. Makidon, Anna U. Bielinska

    Affiliations: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America, Unit for Laboratory Animal Medicine (ULAM), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Anna U. Bielinska equal contributor,

    equal contributor Contributed equally to this work with: Paul E. Makidon, Anna U. Bielinska

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Shraddha S. Nigavekar,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Katarzyna W. Janczak,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Jessica Knowlton,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Alison J. Scott,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Nicholas Mank,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Zhengyi Cao,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Sivaprakash Rathinavelu,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

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  • Michael R. Beer,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • J. Erby Wilkinson,

    Affiliation: Unit for Laboratory Animal Medicine (ULAM), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Luz P. Blanco,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Jeffrey J. Landers,

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • James R. Baker Jr mail

    jbakerjr@umich.edu

    Affiliation: Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: August 13, 2008
  • DOI: 10.1371/journal.pone.0002954

About the Authors

Paul E. Makidon, Anna U. Bielinska, Shraddha S. Nigavekar, Katarzyna W. Janczak, Jessica Knowlton, Alison J. Scott, Nicholas Mank, Zhengyi Cao, Sivaprakash Rathinavelu, Michael R. Beer, Luz P. Blanco, Jeffrey J. Landers, James R. Baker Jr
Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS), University of Michigan, Ann Arbor, Michigan, United States of America
Paul E. Makidon, J. Erby Wilkinson
Unit for Laboratory Animal Medicine (ULAM), University of Michigan, Ann Arbor, Michigan, United States of America

Corresponding Author

Email: jbakerjr@umich.edu

Competing Interests

Interest in NanoBio Corporation, receive Stocks, role as Board Member.

Author Contributions

Conceived and designed the experiments: PEM AUB SSN. Performed the experiments: PEM AUB SSN KWJ JK AJS NM ZC SR MRB JEW LPB JJL. Analyzed the data: PEM AUB SSN KWJ JK AJS NM. Wrote the paper: PEM. PI on this study: JRB.