Suppression of HIV-Specific and Allogeneic T Cell Activation by Human Regulatory T Cells Is Dependent on the Strength of Signals

Amanda K. Antons; Rui Wang; Spyros A. Kalams; Derya Unutmaz

doi:10.1371/journal.pone.0002952

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Open Access

Peer-reviewed

Research Article

Suppression of HIV-Specific and Allogeneic T Cell Activation by Human Regulatory T Cells Is Dependent on the Strength of Signals

Amanda K. Antons,

Affiliation Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Rui Wang,

Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
⨯
Spyros A. Kalams,

Affiliations Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Derya Unutmaz

* E-mail: Derya.Unutmaz@nyumc.org

Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
⨯

Suppression of HIV-Specific and Allogeneic T Cell Activation by Human Regulatory T Cells Is Dependent on the Strength of Signals

Amanda K. Antons,
Rui Wang,
Spyros A. Kalams,
Derya Unutmaz

Published: August 13, 2008
https://doi.org/10.1371/journal.pone.0002952

About the Authors

Amanda K. Antons

Affiliation Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Rui Wang

Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

Spyros A. Kalams

Affiliations Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Derya Unutmaz

* E-mail: Derya.Unutmaz@nyumc.org

Affiliation Department of Microbiology, New York University School of Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DU. Performed the experiments: AKA RW. Analyzed the data: AKA RW DU. Contributed reagents/materials/analysis tools: SAK. Wrote the paper: AKA DU.

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Regulatory T cells
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T cells
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Cytotoxic T cells
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HIV
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Immune response
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T cell receptors
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TCR signaling cascade
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Immune suppression
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