Advertisement
Research Article

Characterization of a Peptide Domain within the GB Virus C NS5A Phosphoprotein that Inhibits HIV Replication

  • Jinhua Xiang,

    Affiliation: Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States of America

    X
  • James H. McLinden,

    Affiliation: Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States of America

    X
  • Qing Chang,

    Affiliation: Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States of America

    X
  • Emma L. Jordan,

    Affiliation: Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States of America

    X
  • Jack T. Stapleton mail

    jack-stapleton@uiowa.edu

    Affiliation: Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States of America

    X
  • Published: July 02, 2008
  • DOI: 10.1371/journal.pone.0002580

About the Authors

Jinhua Xiang, James H. McLinden, Qing Chang, Emma L. Jordan, Jack T. Stapleton
Iowa City VA Medical Center and the University of Iowa, Iowa City, Iowa, United States of America

Corresponding Author

Email: jack-stapleton@uiowa.edu

Competing Interests

Drs. Xiang and Stapleton hold a patent (United States Patent No. 7,291,723) on the use of GBV-C as a therapeutic modality for HIV, and Drs. Xiang, McLinden and Stapleton have a patent application pending related to the use of NS5A as an anti-HIV therapy.

Author Contributions

Conceived and designed the experiments: JS JX JM. Performed the experiments: JX JM QC EJ. Analyzed the data: JS JX JM QC EJ. Contributed reagents/materials/analysis tools: JS JM. Wrote the paper: JS JX JM QC EJ.