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Research Article

The Complement Anaphylatoxin C5a Induces Apoptosis in Adrenomedullary Cells during Experimental Sepsis

  • Michael A. Flierl,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Daniel Rittirsch,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Anthony J. Chen,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Brian A. Nadeau,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Danielle E. Day,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • J. Vidya Sarma,

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Markus S. Huber-Lang,

    Affiliation: Department of Trauma, Hand and Reconstructive Surgery, University of Ulm Medical School, Ulm, Germany

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  • Peter A. Ward mail

    pward@umich.edu

    Affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Published: July 02, 2008
  • DOI: 10.1371/journal.pone.0002560

About the Authors

Michael A. Flierl, Daniel Rittirsch, Anthony J. Chen, Brian A. Nadeau, Danielle E. Day, J. Vidya Sarma, Peter A. Ward
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Markus S. Huber-Lang
Department of Trauma, Hand and Reconstructive Surgery, University of Ulm Medical School, Ulm, Germany

Corresponding Author

Email: pward@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PW MF MH. Performed the experiments: MF DR BN DD AC. Analyzed the data: MF. Wrote the paper: PW MF. Other: Reviewed the manuscript: JS.