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Research Article

Human Umbilical Cord Blood Treatment in a Mouse Model of ALS: Optimization of Cell Dose

  • Svitlana Garbuzova-Davis mail,

    sgarbuzo@health.usf.edu

    Affiliations: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Cyndy Davis Sanberg,

    Affiliation: Saneron CCEL Therapeutics, Inc., Tampa, Florida, United States of America

    X
  • Nicole Kuzmin-Nichols,

    Affiliation: Saneron CCEL Therapeutics, Inc., Tampa, Florida, United States of America

    X
  • Alison E. Willing,

    Affiliations: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Carmelina Gemma,

    Affiliations: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Paula C. Bickford,

    Affiliations: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Christina Miller,

    Affiliation: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Robert Rossi,

    Affiliation: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Paul R. Sanberg

    Affiliations: Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, Florida, United States of America, Department of Psychiatry, College of Medicine, University of South Florida, Tampa, Florida, United States of America

    X
  • Published: June 25, 2008
  • DOI: 10.1371/journal.pone.0002494

About the Authors

Svitlana Garbuzova-Davis, Alison E. Willing, Carmelina Gemma, Paula C. Bickford, Christina Miller, Robert Rossi, Paul R. Sanberg
Center of Excellence for Aging & Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, United States of America
Svitlana Garbuzova-Davis, Alison E. Willing, Carmelina Gemma, Paula C. Bickford, Paul R. Sanberg
Department of Neurosurgery, College of Medicine, University of South Florida, Tampa, Florida, United States of America
Svitlana Garbuzova-Davis, Alison E. Willing, Paul R. Sanberg
Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America
Svitlana Garbuzova-Davis, Alison E. Willing, Paul R. Sanberg
Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, Florida, United States of America
Paul R. Sanberg
Department of Psychiatry, College of Medicine, University of South Florida, Tampa, Florida, United States of America
Cyndy Davis Sanberg, Nicole Kuzmin-Nichols
Saneron CCEL Therapeutics, Inc., Tampa, Florida, United States of America

Corresponding Author

Email: sgarbuzo@health.usf.edu

Competing Interests

SGD, AEW, and PCB are consultants and PRS is a co-founder of Saneron CCEL Therapeutics, Inc.

Author Contributions

Conceived and designed the experiments: PS SG AW. Performed the experiments: CG CM RR. Analyzed the data: SG. Contributed reagents/materials/analysis tools: PB CD NK. Wrote the paper: SG.