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Research Article

Epilepsy in Dcx Knockout Mice Associated with Discrete Lamination Defects and Enhanced Excitability in the Hippocampus

  • Marika Nosten-Bertrand equal contributor,

    equal contributor Contributed equally to this work with: Marika Nosten-Bertrand, Caroline Kappeler, Céline Dinocourt

    Affiliations: INSERM, U513, Université Pierre et Marie Curie, Paris, France, UMPC Université Paris 06, Neurobiologie et Psychiatrie, Paris, France

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  • Caroline Kappeler equal contributor,

    equal contributor Contributed equally to this work with: Marika Nosten-Bertrand, Caroline Kappeler, Céline Dinocourt

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM, U567, Paris, France

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  • Céline Dinocourt equal contributor,

    equal contributor Contributed equally to this work with: Marika Nosten-Bertrand, Caroline Kappeler, Céline Dinocourt

    Affiliation: INSERM, U739, UPMC, CHU Pitié Salpêtrière, Paris, France

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  • Cécile Denis,

    Affiliations: INSERM, U513, Université Pierre et Marie Curie, Paris, France, UMPC Université Paris 06, Neurobiologie et Psychiatrie, Paris, France

    Current address: Celogos, 91058 Evry, France

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  • Johanne Germain,

    Affiliations: INSERM, U513, Université Pierre et Marie Curie, Paris, France, UMPC Université Paris 06, Neurobiologie et Psychiatrie, Paris, France

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  • Françoise Phan Dinh Tuy,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM, U567, Paris, France

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  • Soraya Verstraeten,

    Affiliations: INSERM, U513, Université Pierre et Marie Curie, Paris, France, UMPC Université Paris 06, Neurobiologie et Psychiatrie, Paris, France

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  • Chantal Alvarez,

    Affiliations: UPMC, Paris, France, INSERM, U839, Institut du Fer à Moulin, Paris, France

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  • Christine Métin,

    Affiliations: UPMC, Paris, France, INSERM, U839, Institut du Fer à Moulin, Paris, France

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  • Jamel Chelly,

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM, U567, Paris, France

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  • Bruno Giros,

    Affiliations: INSERM, U513, Université Pierre et Marie Curie, Paris, France, UMPC Université Paris 06, Neurobiologie et Psychiatrie, Paris, France, Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada

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  • Richard Miles,

    Affiliation: INSERM, U739, UPMC, CHU Pitié Salpêtrière, Paris, France

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  • Antoine Depaulis,

    Affiliation: Grenoble Institute of Neurosciences, Inserm U836-UJF-CEA-CHU, Université Joseph Fourier, Grenoble, France

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  • Fiona Francis mail

    francis@cochin.inserm.fr

    Affiliations: Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France, INSERM, U567, Paris, France

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  • Published: June 25, 2008
  • DOI: 10.1371/journal.pone.0002473

About the Authors

Marika Nosten-Bertrand, Cécile Denis, Johanne Germain, Soraya Verstraeten, Bruno Giros
INSERM, U513, Université Pierre et Marie Curie, Paris, France
Marika Nosten-Bertrand, Cécile Denis, Johanne Germain, Soraya Verstraeten, Bruno Giros
UMPC Université Paris 06, Neurobiologie et Psychiatrie, Paris, France
Caroline Kappeler, Françoise Phan Dinh Tuy, Jamel Chelly, Fiona Francis
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France
Caroline Kappeler, Françoise Phan Dinh Tuy, Jamel Chelly, Fiona Francis
INSERM, U567, Paris, France
Céline Dinocourt, Richard Miles
INSERM, U739, UPMC, CHU Pitié Salpêtrière, Paris, France
Chantal Alvarez, Christine Métin
UPMC, Paris, France
Chantal Alvarez, Christine Métin
INSERM, U839, Institut du Fer à Moulin, Paris, France
Bruno Giros
Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, Quebec, Canada
Antoine Depaulis
Grenoble Institute of Neurosciences, Inserm U836-UJF-CEA-CHU, Université Joseph Fourier, Grenoble, France

Corresponding Author

Email: francis@cochin.inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RM MN FF AD. Performed the experiments: CM MN FF CK CDinocourt CDenis JG SV CA FP AD. Analyzed the data: RM CM MN FF CK CDinocourt CDenis JG SV CA FP AD. Contributed reagents/materials/analysis tools: MN FF CK. Wrote the paper: RM MN FF CK CDinocourt AD. Other: Head of the laboratory: BG RM AD JC. Animal breeding and genotyping: MN.