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Research Article

Knockdown of Cytosolic Glutaredoxin 1 Leads to Loss of Mitochondrial Membrane Potential: Implication in Neurodegenerative Diseases

  • Uzma Saeed,

    Affiliation: Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India

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  • Lalitha Durgadoss,

    Affiliation: Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India

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  • R. Khader Valli,

    Affiliation: Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India

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  • Dinesh C. Joshi,

    Affiliation: Department of Biophysics, National Institute of Mental Health and Neurosciences, Bangalore, India

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  • Preeti G. Joshi,

    Affiliation: Department of Biophysics, National Institute of Mental Health and Neurosciences, Bangalore, India

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  • Vijayalakshmi Ravindranath mail

    vijir@nbrc.ac.in

    Affiliation: Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India

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  • Published: June 18, 2008
  • DOI: 10.1371/journal.pone.0002459

About the Authors

Uzma Saeed, Lalitha Durgadoss, R. Khader Valli, Vijayalakshmi Ravindranath
Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
Dinesh C. Joshi, Preeti G. Joshi
Department of Biophysics, National Institute of Mental Health and Neurosciences, Bangalore, India

Corresponding Author

Email: vijir@nbrc.ac.in

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VR US. Performed the experiments: US LD KV. Analyzed the data: US LD KV. Contributed reagents/materials/analysis tools: US. Wrote the paper: VR US. Other: Helped with the experiments and writing of the paper: PJ DJ.