About the Authors

Alison Wood-Kaczmar

Contributed equally to this work with: Alison Wood-Kaczmar, Sonia Gandhi

Affiliation Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

Sonia Gandhi

Contributed equally to this work with: Alison Wood-Kaczmar, Sonia Gandhi

Affiliations Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom, Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom

Zhi Yao

Affiliation Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

Andrey S. Y. Abramov

Affiliation Department of Physiology, University College London, London, United Kingdom

Erik A. Miljan

Affiliation ReNeuron Ltd, Guildford, United Kingdom

Gregory Keen

Affiliation Eisai London Research Laboratories Ltd, London, United Kingdom

Lee Stanyer

Affiliation Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

Iain Hargreaves

Affiliation Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom

Kristina Klupsch

Affiliation Cancer Research United Kingdom, London, United Kingdom

Emma Deas

Affiliation Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

Julian Downward

Affiliation Cancer Research United Kingdom, London, United Kingdom

Louise Mansfield

Affiliation Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

Parmjit Jat

Affiliation Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

Joanne Taylor

Affiliation Eisai London Research Laboratories Ltd, London, United Kingdom

Simon Heales

Affiliations Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom, Neurometabolic Unit, National Hospital for Neurology and Neurosurgery, London, United Kingdom

Michael R. Duchen

Affiliation Department of Physiology, University College London, London, United Kingdom

David Latchman

Affiliations Medical Molecular Biology Unit, Institute of Child Health, London, United Kingdom, Birkbeck, University of London, London, United Kingdom

Sarah J. Tabrizi

These authors also contributed equally to this work.

Affiliation Department of Neurodegenerative Disease, Institute of Neurology, London, United Kingdom

Nicholas W. Wood

n.wood@ion.ucl.ac.uk

These authors also contributed equally to this work.

Affiliation Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JD ST NW SG LM PJ JT SH MD DL AW. Performed the experiments: SG ZY AA EM GK LS IH KK AW ED. Analyzed the data: ST SG AA LS IH SH AW. Contributed reagents/materials/analysis tools: JD ST EM GK LM PJ JT SH MD DL ED. Wrote the paper: SG AW.