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Research Article

Multivalent HA DNA Vaccination Protects against Highly Pathogenic H5N1 Avian Influenza Infection in Chickens and Mice

  • Srinivas Rao,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Wing-Pui Kong,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Chih-Jen Wei,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Zhi-Yong Yang,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Martha Nason,

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Darrel Styles,

    Affiliation: United States Department of Agriculture, Animal and Plant Health Inspection Service, Riverdale, Maryland, United States of America

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  • Louis J. DeTolla,

    Affiliation: Comparative Medicine, University of Maryland Baltimore, Baltimore, Maryland, United States of America

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  • Erin M. Sorrell,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Haichen Song,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Hongquan Wan,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Gloria C. Ramirez-Nieto,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Daniel Perez,

    Affiliation: College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America

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  • Gary J. Nabel mail

    gnabel@nih.gov

    Affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: June 18, 2008
  • DOI: 10.1371/journal.pone.0002432

About the Authors

Srinivas Rao, Wing-Pui Kong, Chih-Jen Wei, Zhi-Yong Yang, Martha Nason, Gary J. Nabel
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Darrel Styles
United States Department of Agriculture, Animal and Plant Health Inspection Service, Riverdale, Maryland, United States of America
Erin M. Sorrell, Haichen Song, Hongquan Wan, Gloria C. Ramirez-Nieto, Daniel Perez
College of Veterinary Medicine, University of Maryland, College Park, Maryland, United States of America
Louis J. DeTolla
Comparative Medicine, University of Maryland Baltimore, Baltimore, Maryland, United States of America

Corresponding Author

Email: gnabel@nih.gov

Competing Interests

The authors W.-P.K, C.-J.W, Z.-Y.Y, S.R and G.J.N. have submitted an intellectual property application based on findings reported in this study.

Author Contributions

Conceived and designed the experiments: GN WK ZY DP SR CW DS. Performed the experiments: WK ZY DP LD SR CW ES HS HW GR. Analyzed the data: GN WK ZY DP MN SR CW DS. Wrote the paper: GN WK ZY DP SR CW DS.