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Research Article

Non-Syndromic Tooth Agenesis in Two Chinese Families Associated with Novel Missense Mutations in the TNF Domain of EDA (Ectodysplasin A)

  • Shufeng Li equal contributor,

    equal contributor Contributed equally to this work with: Shufeng Li, Jiahuang Li, Jian Cheng, Bingrong Zhou, Xin Tong

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Jiahuang Li equal contributor,

    equal contributor Contributed equally to this work with: Shufeng Li, Jiahuang Li, Jian Cheng, Bingrong Zhou, Xin Tong

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Jian Cheng equal contributor,

    equal contributor Contributed equally to this work with: Shufeng Li, Jiahuang Li, Jian Cheng, Bingrong Zhou, Xin Tong

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Bingrong Zhou equal contributor,

    equal contributor Contributed equally to this work with: Shufeng Li, Jiahuang Li, Jian Cheng, Bingrong Zhou, Xin Tong

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Xin Tong equal contributor,

    equal contributor Contributed equally to this work with: Shufeng Li, Jiahuang Li, Jian Cheng, Bingrong Zhou, Xin Tong

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Xiangbai Dong,

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Zixing Wang,

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Qingang Hu,

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Meng Chen,

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Zi-Chun Hua mail

    zchua@nju.edu.cn

    Affiliation: The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

    X
  • Published: June 11, 2008
  • DOI: 10.1371/journal.pone.0002396

About the Authors

Shufeng Li, Jiahuang Li, Jian Cheng, Bingrong Zhou, Xin Tong, Xiangbai Dong, Zixing Wang, Qingang Hu, Meng Chen, Zi-Chun Hua
The State Key Laboratory of Pharmaceutical Biotechnology, Nanjing Stomatological Hospital, Nanjing University, Nanjing, People's Republic of China

Corresponding Author

Email: zchua@nju.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZH. Performed the experiments: SL JC XD ZW MC. Analyzed the data: ZH SL JL JC. Wrote the paper: ZH SL JL. Other: Collected samples: XT BZ. Clinical diagnosis: BZ QH.