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Research Article

A Novel Role for PECAM-1 (CD31) in Regulating Haematopoietic Progenitor Cell Compartmentalization between the Peripheral Blood and Bone Marrow

  • Ewan A. Ross,

    Affiliation: Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom

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  • Sylvie Freeman,

    Affiliation: Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom

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  • Yan Zhao,

    Affiliation: Center for Cardiovascular Studies, University of Birmingham, Birmingham, United Kingdom

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  • Tarvinder S. Dhanjal,

    Affiliation: Center for Cardiovascular Studies, University of Birmingham, Birmingham, United Kingdom

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  • Emma J. Ross,

    Affiliation: Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom

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  • Sian Lax,

    Affiliation: Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom

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  • Zubair Ahmed,

    Affiliation: Molecular Neuroscience Group, University of Birmingham, Birmingham, United Kingdom

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  • Tie Zheng Hou,

    Affiliation: Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom

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  • Neena Kalia,

    Affiliation: Center for Cardiovascular Studies, University of Birmingham, Birmingham, United Kingdom

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  • Stuart Egginton,

    Affiliation: Department of Physiology, University of Birmingham, Birmingham, United Kingdom

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  • Gerard Nash,

    Affiliation: Center for Cardiovascular Studies, University of Birmingham, Birmingham, United Kingdom

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  • Steve P. Watson,

    Affiliation: Center for Cardiovascular Studies, University of Birmingham, Birmingham, United Kingdom

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  • Jon Frampton,

    Affiliation: Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom

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  • Christopher D. Buckley mail

    c.d.buckley@bham.ac.uk

    Affiliation: Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom

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  • Published: June 04, 2008
  • DOI: 10.1371/journal.pone.0002338

About the Authors

Ewan A. Ross, Emma J. Ross, Sian Lax, Tie Zheng Hou, Christopher D. Buckley
Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom
Sylvie Freeman, Jon Frampton
Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
Yan Zhao, Tarvinder S. Dhanjal, Neena Kalia, Gerard Nash, Steve P. Watson
Center for Cardiovascular Studies, University of Birmingham, Birmingham, United Kingdom
Zubair Ahmed
Molecular Neuroscience Group, University of Birmingham, Birmingham, United Kingdom
Stuart Egginton
Department of Physiology, University of Birmingham, Birmingham, United Kingdom

Corresponding Author

Email: c.d.buckley@bham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GN SE CB ER SF TD SW JF. Performed the experiments: ER YZ TD ER SL ZA TH NK. Analyzed the data: CB ER SF ZA TH NK. Contributed reagents/materials/analysis tools: SE. Wrote the paper: GN CB ER SF SW JF.