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Research Article

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

  • Jamie L. Barger,

    Affiliation: LifeGen Technologies, LLC, Madison, Wisconsin, United States of America

    X
  • Tsuyoshi Kayo,

    Affiliation: LifeGen Technologies, LLC, Madison, Wisconsin, United States of America

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  • James M. Vann,

    Affiliations: Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Edward B. Arias,

    Affiliation: Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jelai Wang,

    Affiliation: Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Timothy A. Hacker,

    Affiliation: Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Ying Wang,

    Affiliation: R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland

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  • Daniel Raederstorff,

    Affiliation: R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland

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  • Jason D. Morrow,

    Affiliations: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Christiaan Leeuwenburgh,

    Affiliation: Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • David B. Allison,

    Affiliation: Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Kurt W. Saupe,

    Affiliation: Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Gregory D. Cartee,

    Affiliation: Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Richard Weindruch mail,

    rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

    Affiliation: Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Tomas A. Prolla mail

    rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

    Affiliations: Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Published: June 04, 2008
  • DOI: 10.1371/journal.pone.0002264

About the Authors

Jamie L. Barger, Tsuyoshi Kayo
LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
James M. Vann, Tomas A. Prolla
Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
James M. Vann, Tomas A. Prolla
Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
Edward B. Arias, Gregory D. Cartee
Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America
Jelai Wang
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Timothy A. Hacker, Kurt W. Saupe
Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
Ying Wang, Daniel Raederstorff
R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland
Jason D. Morrow
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Jason D. Morrow
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Christiaan Leeuwenburgh
Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America
David B. Allison
Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Richard Weindruch
Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Corresponding Authors

Competing Interests

T.A. Prolla and R. Weindruch are founders and board directors of LifeGen Technologies, LLC, a company focused on the use of gene expression profiling to understand the mechanisms of action of caloric restriction.

Author Contributions

Conceived and designed the experiments: TP RW. Performed the experiments: TK JV EA TH. Analyzed the data: TP JW RW JB. Contributed reagents/materials/analysis tools: DA JW GC CL KS YW DR JM. Wrote the paper: TP RW JB.