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Research Article

The Proto-Oncogene Int6 Is Essential for Neddylation of Cul1 and Cul3 in Drosophila

  • Sigal Rencus-Lazar,

    Affiliations: Department of Molecular Microbiology, Tel Aviv University, Tel Aviv, Israel, Department of Biotechnology, Tel Aviv University, Tel Aviv, Israel

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  • Yaniv Amir,

    Affiliations: Department of Molecular Microbiology, Tel Aviv University, Tel Aviv, Israel, Department of Biotechnology, Tel Aviv University, Tel Aviv, Israel

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  • Junetai Wu,

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

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  • Cheng-Ting Chien,

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

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  • Daniel A. Chamovitz mail,

    dannyc@ex.tau.ac.il (DC); dsegal@post.tau.ac.il (DS)

    Affiliation: Department of Plant Sciences, Tel Aviv University, Tel Aviv, Israel

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  • Daniel Segal mail

    dannyc@ex.tau.ac.il (DC); dsegal@post.tau.ac.il (DS)

    Affiliations: Department of Molecular Microbiology, Tel Aviv University, Tel Aviv, Israel, Department of Biotechnology, Tel Aviv University, Tel Aviv, Israel

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  • Published: May 21, 2008
  • DOI: 10.1371/journal.pone.0002239

About the Authors

Sigal Rencus-Lazar, Yaniv Amir, Daniel Segal
Department of Molecular Microbiology, Tel Aviv University, Tel Aviv, Israel
Sigal Rencus-Lazar, Yaniv Amir, Daniel Segal
Department of Biotechnology, Tel Aviv University, Tel Aviv, Israel
Junetai Wu, Cheng-Ting Chien
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
Daniel A. Chamovitz
Department of Plant Sciences, Tel Aviv University, Tel Aviv, Israel

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DS DC SR. Performed the experiments: SR YA JW. Analyzed the data: DS DC SR CC. Contributed reagents/materials/analysis tools: JW CC. Wrote the paper: DS DC SR.