Advertisement
Research Article

Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process

  • Wolfgang Wagner mail,

    wolfgang_wagner@med.uni-heidelberg.de

    Affiliations: Department of Medicine V, University of Heidelberg, Heidelberg, Germany, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany

    X
  • Patrick Horn,

    Affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany

    X
  • Mirco Castoldi,

    Affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

    X
  • Anke Diehlmann,

    Affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany

    X
  • Simone Bork,

    Affiliations: Department of Medicine V, University of Heidelberg, Heidelberg, Germany, Heidelberg Academy of Sciences and Humanities, Heidelberg, Germany

    X
  • Rainer Saffrich,

    Affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany

    X
  • Vladimir Benes,

    Affiliation: Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany

    X
  • Jonathon Blake,

    Affiliation: Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany

    X
  • Stefan Pfister,

    Affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany

    X
  • Volker Eckstein,

    Affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany

    X
  • Anthony D. Ho

    Affiliation: Department of Medicine V, University of Heidelberg, Heidelberg, Germany

    X
  • Published: May 21, 2008
  • DOI: 10.1371/journal.pone.0002213

About the Authors

Wolfgang Wagner, Patrick Horn, Anke Diehlmann, Simone Bork, Rainer Saffrich, Volker Eckstein, Anthony D. Ho
Department of Medicine V, University of Heidelberg, Heidelberg, Germany
Wolfgang Wagner
Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
Vladimir Benes, Jonathon Blake
Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany
Mirco Castoldi, Stefan Pfister
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany
Simone Bork
Heidelberg Academy of Sciences and Humanities, Heidelberg, Germany

Corresponding Author

Email: wolfgang_wagner@med.uni-heidelberg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VB WW PH MC SP AH. Performed the experiments: PH MC AD SB RS VE. Analyzed the data: WW PH MC SB RS JB SP VE AH. Contributed reagents/materials/analysis tools: VB MC AD RS JB VE. Wrote the paper: WW AH.