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Research Article

Adaptive Evolution and Functional Redesign of Core Metabolic Proteins in Snakes

  • Todd A. Castoe equal contributor,

    equal contributor Contributed equally to this work with: Todd A. Castoe, Zhi J. Jiang

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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  • Zhi J. Jiang equal contributor,

    equal contributor Contributed equally to this work with: Todd A. Castoe, Zhi J. Jiang

    Affiliation: Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, Baton Rouge, Louisiana, United States of America

    Current address: Computational Biology, Scripps Florida, Jupiter, Florida, United States of America

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  • Wanjun Gu,

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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  • Zhengyuan O. Wang,

    Affiliation: Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, Baton Rouge, Louisiana, United States of America

    Current address: Genome Sequencing Center, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • David D. Pollock mail

    David.Pollock@uchsc.edu

    Affiliation: Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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  • Published: May 21, 2008
  • DOI: 10.1371/journal.pone.0002201

About the Authors

Todd A. Castoe, Wanjun Gu, David D. Pollock
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America
Zhi J. Jiang, Zhengyuan O. Wang
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, Baton Rouge, Louisiana, United States of America

Corresponding Author

Email: David.Pollock@uchsc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DP. Performed the experiments: TC ZJ. Analyzed the data: DP TC ZJ WG ZW. Contributed reagents/materials/analysis tools: DP WG. Wrote the paper: DP TC ZJ.