About the Authors

Jeremy L. Peirce

jpeirce@utmem.edu

Affiliations Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Center for Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Karl W. Broman

Affiliation Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland, United States of America

Lu Lu

Affiliations Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Center for Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Elissa J. Chesler

Affiliations Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Center for Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Guomin Zhou

Affiliation Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

David C. Airey

Affiliation Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Amanda E. Birmingham

Affiliation Dharmacon, Inc., Lafayette, Colorado, United States of America

Robert W. Williams

Affiliations Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Center for Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RW JP KB. Performed the experiments: JP. Analyzed the data: DA EC JP. Contributed reagents/materials/analysis tools: RW LL GZ. Wrote the paper: JP. Other: Generated AILs whose analysis is discussed in the paper and provided editiorial comments and support: RW. Generated AILs whose analysis is discussed in the paper and provided editorial comments and support: LL. Helped with writing and presentation of code: AB. Provided suggestions for approaches and analyzed early AIL data for this cross: DA. Provided useful discussions on analysis of AILs: EC. Wrote the code: JP. Generated AIL population used for analysis in this paper: GZ. Provided initial idea for GRAIP as well as suggestions for symbolic representation of the process: KB.