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Research Article

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

  • Tiago Fleming Outeiro mail,

    touteiro@fm.ul.pt (TO); pmclean@partners.org (PM)

    Affiliations: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America, Instituto de Medicina Molecular, Cell and Molecular Neuroscience Unit, Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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  • Preeti Putcha,

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Julie E. Tetzlaff,

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Robert Spoelgen,

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Mirjam Koker,

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Filipe Carvalho,

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Bradley T. Hyman,

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Pamela J. McLean mail

    touteiro@fm.ul.pt (TO); pmclean@partners.org (PM)

    Affiliation: Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America

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  • Published: April 02, 2008
  • DOI: 10.1371/journal.pone.0001867

About the Authors

Tiago Fleming Outeiro, Preeti Putcha, Julie E. Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T. Hyman, Pamela J. McLean
Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH Harvard Medical School, Charlestown, Massachusetts, United States of America
Tiago Fleming Outeiro
Instituto de Medicina Molecular, Cell and Molecular Neuroscience Unit, Instituto de Fisiologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BH TO RS PM. Performed the experiments: TO PP JT RS MK FC. Analyzed the data: TO PP. Contributed reagents/materials/analysis tools: TO PP PM. Wrote the paper: BH TO PM.