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Research Article

Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels

  • Federica Chiara,

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Diego Castellaro,

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Oriano Marin,

    Affiliation: Department of Biological Chemistry and Venetian Institute of Molecular Medicine (VIMM), University of Padova, Padova, Italy

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  • Valeria Petronilli,

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • William S. Brusilow,

    Affiliation: Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

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  • Magdalena Juhaszova,

    Affiliation: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Steven J. Sollott,

    Affiliation: Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Michael Forte,

    Affiliation: Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Paolo Bernardi mail,

    bernardi@bio.unipd.it (PB); rasola@bio.unipd.it (AR)

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Andrea Rasola mail

    bernardi@bio.unipd.it (PB); rasola@bio.unipd.it (AR)

    Affiliation: CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy

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  • Published: March 19, 2008
  • DOI: 10.1371/journal.pone.0001852

About the Authors

Federica Chiara, Diego Castellaro, Valeria Petronilli, Paolo Bernardi, Andrea Rasola
CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy
Oriano Marin
Department of Biological Chemistry and Venetian Institute of Molecular Medicine (VIMM), University of Padova, Padova, Italy
William S. Brusilow
Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
Magdalena Juhaszova, Steven J. Sollott
Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Michael Forte
Vollum Institute, Oregon Health & Science University, Portland, Oregon, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS PB AR FC MJ. Performed the experiments: SS FC DC WB MJ. Analyzed the data: MF AR FC VP WB. Contributed reagents/materials/analysis tools: OM. Wrote the paper: PB AR.